Although the terms ON and OFF have been used to describe responses to levodopa therapy for more than 40 years, there is still no universally agreed-upon definition for the term OFF, and everyone with Parkinson's experiences it differently. OFF periods occur when your medication isn't working optimally, and your motor and non-motor symptoms return. OFF is much more nuanced but understanding its scientific causes can help you minimize it in your daily life.
After being diagnosed with Parkinson’s, one of the most common questions is “Why?” We have seen many exciting breakthroughs in recent research, but we still don’t have a clear answer as to exactly what causes Parkinson’s. However, there are several promising advances that suggest various roots of Parkinson’s, as well as new insights that challenge century-old assumptions.
Pete Schmidt talks about how Parkinson’s is really a disease of this.
Kelsey Phinney shares her story & breaks down the science of Parkinson’s.