“partial ON”

16 Nov: The Science of Parkinson’s OFF

Although the terms ON and OFF have been used to describe responses to levodopa therapy for more than 40 years, there is still no universally agreed-upon definition for the term OFF, and everyone with Parkinson's experiences it differently. OFF periods occur when your medication isn't working optimally, and your motor and non-motor symptoms return. OFF is much more nuanced but understanding its scientific causes can help you minimize it in your daily life.