Tricyclic Antidepressants

TCAs are another class of medications used to treat depression, anxiety, and OCD. They are prescribed less often than SSRIs and SNRIs due to higher likelihood of side effects. Possible side effects include dry mouth, constipation, orthostatic hypotension, urinary retention, and confusion. People with heart conditions (such as arrhythmia or QTc prolongation) should use TCAs with caution. Like SSRIs and SNRIs, it often takes four to six weeks after reaching a therapeutic dose for them to take effect. These medications should be used with caution in conjunction with other serotonergic medications due to a potential for serotonin syndrome.

Generic Name
Trade Name
Patient Assistance
Amitriptyline Elavil® Often used at bedtime due to possible sedation. Product Website More Information
Nortriptyline Sensoval®, Aventyl®, Pamelor® May have fewer side effects than other TCAs. Pamelor Product Website Mallinckrodt Patient Assistance
Imipramine Tofranil®, Tofranil® PM Product Website Mallinckrodt Patient Assistance

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