Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

SNRIs are another class of antidepressants that can treat depression, anxiety, and OCD. Like SSRIs, it often takes four to six weeks after reaching a therapeutic dose for them to take effect. SNRIs can raise blood pressure, and other possible side effects include headache, nausea, sexual dysfunction, and dizziness. Like SSRIs, SNRIs should be used with caution in conjunction with other serotonergic medications due to a potential for serotonin syndrome.

Generic Name
Trade Name
Patient Assistance
Duloxetine Cymbalta® Some research suggests a reduction in OFF time. May also have pain benefit. Product Website Lilly Cares Foundation Patient Assistance More Information
Venlafaxine Effexor® or Effexor® XR May have pain benefit. Product Website Patient Assistance
Desvenlafaxine Pristiq® Product Website Pfizer Patient Assistance
Milnacipran Savella® Approved to treat chronic pain from fibromyalgia; sometimes used off-label to treat depression and anxiety. Product Website Allergan Savings Program More Information
Nefazodone Serzone® Requires periodic monitoring of liver function. Product Website Teva Patient Assistance

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