Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs are the most commonly prescribed antidepressants for Parkinson’s-related depression because of their tolerability. These medications can also used to treat anxiety and obsessive-compulsive disorder (OCD). It often takes four to six weeks of a therapeutic dose for full effect. SSRIs are sometimes combined with other medications such SNRIs and TCAs (see tables below), but such combinations should be used with caution due to a potential for serotonin syndrome. Possible side effects include headache, nausea, insomnia, jitteriness, sexual dysfunction, and weight gain.

Generic Name
Trade Name
Notes
Link
Patient Assistance
Brochure
Escitalopram Lexapro® Product Website
Citalopram Celexa® Product Website Allergen Patient Assistance
Fluoxetine Prozac® Prescribing Information Lilly Cares Foundation Patient Assistance
Fluvoxamine Generic or Luvox® CR Product Website Teva Patient Assistance
Paroxetine Paxil®, Paxil® CR, Pexeva® Possibly more benefit for anxiety than other SSRIs. Possibly more anticholinergic side effects (e.g. dry mouth, constipation). May cause weight gain. Product Website
Sertraline Zoloft® Product Website Pfizer Patient Assistance

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