Other Antidepressants

These medications can also have benefit for depression, anxiety, and OCD. Like SSRIs, SNRIs, and TCAs, it often takes four to six weeks after reaching a therapeutic dose for these drugs to take effect. Some of these medications should be used with caution in conjunction with serotonergic medications due to a potential for serotonin syndrome.

Generic Name
Trade Name
Patient Assistance
Bupropion Wellbutrin®, Wellbutrin® XL Less likely than other antidepressants to cause weight gain or sexual side effects. More likely than other side antidepressants to have tremor as a side effect. Product Website Bausch Savings Program More Information
Mirtazapine Remeron® May cause sedation (also used to help with insomnia) or increased appetite (also used to help with weight gain). Also available as a dissolvable pill, which can be an advantage for people with swallowing problems. Prescribing Information Merck Patient Assistance
Trazodone Desyrel®, Oleptro™, Trialodine® May cause sedation (also used to help with insomnia). Product Website Teva Patient Assistance
Vilazodone Viibryd® Product Website Viibryd Savings Program
Vortioxetine Trintellix®

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