MAO-B Inhibitors

Monoamine Oxidase Type B (MAO-B) inhibitors act to block an enzyme that breaks down dopamine, which allows more dopamine to be available to the brain. Like levodopa and dopamine agonists, MAO-B inhibitors are used to treat slowness, stiffness, and tremor. They can be used on their own, though they typically have a milder benefit than levodopa and dopamine agonists. MAO-B inhibitors are often used as supplemental medications to reduce OFF time. Common side effects include nausea, light-headedness, and insomnia. Because MAO-B inhibitors increase and prolong the effects of dopamine, the side effects of dopamine may also be enhanced, including dyskinesia. There are multiple medications that are contraindicated with MAO-B inhibitors (see table).

Generic Name
Trade Name
Patient Assistance
Selegiline Eldepryl® May cause anxiety, irritability, or insomnia. Prescribing Information
Selegiline HCL orally disintegrating Zelapar® May cause anxiety, irritability, or insomnia. Dissolvable pill can be an advantage for people with swallowing problems. Prescribing Information Bausch Health Patient Assistance
Rasagiline Azilect® Product Website Teva Patient Assistance
Safinamide XADAGO® Approved 2017; approved as an add-on to carbidopa/levodopa to address OFF time. Product Website XADAGO Savings and Support More Information

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