MAO-B Inhibitors
Monoamine Oxidase Type B (MAO-B) inhibitors act to block an enzyme that breaks down dopamine, which allows more dopamine to be available to the brain. Like levodopa and dopamine agonists, MAO-B inhibitors are used to treat slowness, stiffness, and tremor. They can be used on their own, though they typically have a milder benefit than levodopa and dopamine agonists. MAO-B inhibitors are often used as supplemental medications to reduce OFF time. Common side effects include nausea, light-headedness, and insomnia. Because MAO-B inhibitors increase and prolong the effects of dopamine, the side effects of dopamine may also be enhanced, including dyskinesia. There are multiple medications that are contraindicated with MAO-B inhibitors (see table).
Generic Name |
Trade Name |
Notes |
Link |
Patient Assistance |
Brochure |
|---|---|---|---|---|---|
| Selegiline | Eldepryl® | May cause anxiety, irritability, or insomnia. | Prescribing Information | ||
| Selegiline HCL orally disintegrating | Zelapar® | May cause anxiety, irritability, or insomnia. Dissolvable pill can be an advantage for people with swallowing problems. | Prescribing Information | Bausch Health Patient Assistance | |
| Rasagiline | Azilect® | Product Website | Teva Patient Assistance | ||
| Safinamide | XADAGO® | Approved 2017; approved as an add-on to carbidopa/levodopa to address OFF time. | Product Website | XADAGO Savings and Support | More Information |