Fatigue means low energy and is a common symptom in Parkinson’s. Fatigue often overlaps with sleepiness and/or depression. Because medication treatment options for fatigue may be of limited benefit, treatment of any overlapping sleepiness or depression is paramount. Lifestyle changes are also important, including budgeting energy for your most important activities, exercising regularly, eating well, drinking lots of water, getting enough sleep, and taking breaks when needed. Spending time with other people helps some people feel more engaged and energetic Medications can have some benefit for fatigue. Possible side effects include headache, dizziness, anxiety, nervousness, and insomnia.

Generic Name
Trade Name
Patient Assistance
Modafinil Provigil Approved to treat excessive sleepiness among people with sleep apnea or narcolepsy; used off-label for Parkinson’s. Product Website Teva Patient Assistance
Methylphenidate Ritalin Approved to treat ADHD and narcolepsy; used off-label for Parkinson’s.
Should not be take with MAO-B inhibitors.
Prescribing Information Novartis Patient Assistance

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