COMT Inhibitors
Catechol-o-methyl transferase (COMT) inhibitors block levodopa metabolism, prolonging levodopa effects. COMT inhibitors thus have no effect on their own and are always used in conjunction with levodopa. COMT inhibitors are used primarily to treat motor fluctuations and reduce OFF time. Possible side effects include diarrhea and discolored urine. Because COMT inhibitors increase and prolong the effects of levodopa, the side effects of levodopa may also be enhanced, including dyskinesia.
Generic Name |
Trade Name |
Notes |
Link |
Patient Assistance |
Brochure |
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Entacapone | Comtan® | Prescribing Information | |||
Tolcapone | Tasmar® | Rare but possible serious side effects on the liver, so typically only used if other Parkinson’s medications have failed. | |||
Carbidopa/Levodopa/Entacapone | Stalevo® | An alternative to just carbidopa/levodopa that is combined with entacapone to help with motor fluctuations. | Product Website | Novartis Patient Assistance | |
Opicapone | Ongentys® | Approved 2020. Once-daily dosing. | Prescribing Information |