Adenosine Receptor Antagonist

Adenosine receptor antagonists act to block the reception sites for the neurotransmitter adenosine, which acts as a central nervous system depressant. This medication is approved for use in conjunction with carbidopa/levodopa to help reduce OFF time. These medications can increase ON time without troublesome dyskinesias for many people, but dyskinesias are the most common side effect.

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Istradefylline Nourianz® NOURIANZ® (Istradefylline) is the first and only medicine for Parkinson’s that targets the adenosine A2A receptor. NOURIANZ® is indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson’s experiencing OFF episodes (times when symptoms return). Istradefylline and levodopa together have been proven to help improve motor activity in patients with Parkinson’s.

Those who smoke 20 or more cigarettes a day will require an increased dosage.

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